Command & Conquer 4: Tiberian Twilight is a real-time tactics video game and the latest installment of the popular Command & Conquer franchise, released March 16, 2010. It constitutes the final chapter in the Kane saga. Command & Conquer 4 is the first game in the series to implement a form of DRM that requires constant Internet access; this type of restrictive DRM is fairly new and targets the used games market as well as ensuring that households must buy a copy per person. Command & Conquer 4 also utilizes EA's own servers for online play, rather than Gamespy Servers which EA has relied on for previous Command & Conquer games. A closed beta of the game was officially released by EA to contest winners on November 21, 2009.

The gameplay in Command & Conquer 4 no longer follows the same resource-gathering dynamic as previous games in the series. In the main game mode, the player must capture control nodes scattered across a map, and retain more nodes than the enemy player, gaining enough points over time to win the match. Command & Conquer 4 utilizes class-based gameplay as well as some RPG elements.
There are two playable factions: the GDI and the Brotherhood of Nod. The storyline begins with the world being consumed by the rampant growth of Tiberium, which is threatening to render the earth uninhabitable. Each faction is split into three upgradeable classes: offence, defense and support, each with their own specialized focus. The classes consist mostly of their own unique units, with the only shared unit among classes being the engineer. The offence class is focused on tank-based, front-line combat, relying less on any kind of fortified emplacements or bases. The defence class is focused on infantry-based combat as well as utilization of rudimentary base defenses, and are also the only class to have access to superweapons. The support class is focused on air-combat and specialized vehicles to traverse the environment, and is also equipped with special support powers that are used to assist teammates. Command & Conquer 4 contains two non-playable factions from previous games in the Tiberium Universe: The Scrin (C&C3) and the Forgotten (Tiberian Sun), the latter of which returning as a minor part of the story as well as a neutral class on the map. Command & Conquer 4 includes a total of about 90 units, including many new units and updated versions of previous Command & Conquer units. The GDI utilizes walkers and powered armor infantry for its army whereas Nod primarily relies on cyborgs and treaded vehicles.
In Command and Conquer 4: Tiberian Twilight, each faction features its own campaign with the story told and played out from their perspective, each resulting in an ultimate conclusion to the Kane saga. In addition to the two brief single player campaigns, Command & Conquer 4: Tiberian Twilight features a cooperative campaign mode, which will allow multi-class play and integrated player progression. The difficulty in co-op campaign mode varies depending on the player's level, and objectives will be shared. Campaigns for both factions take place simultaneously.

Tiberian Twilight is the final game in the Tiberium Universe to feature Kane. The prologue to the game takes place in the year 2062, 15 years after the events of Tiberium Wars which led to the invasion and defeat of the Scrin, and 10 years after the final events of Kane's Wrath, where the prophet regained possession of the Tacitus. During this time period, Tiberium has evolved and is spreading at such a rate that the whole planet is expected to become uninhabitable by 2068. Humanity is on the brink of extinction.
At this time of crisis, the leader of the Brotherhood of Nod, Kane, heads straight for the headquarters of the Global Defense Initiative, in hopes of using the Tacitus and GDI's resources to construct a worldwide Tiberium Control Network, which would allow the spread of Tiberium to be controlled, as well as turn it into an inexpensive power source. Even though the idea of alliance was met with hostility by many (which sparked a brief Incursion War conflict), the two factions have nevertheless united. The campaign itself starts 15 years after the formation of the alliance between the two factions, as the Tiberium Control Network is nearing completion, and the spread of Tiberium is finally stopped, bringing the light of optimism to the world's remaining population. However, extremists from both factions cause unrest, which sparks the Fourth Tiberium War. The player takes the role of commander Parker, a GDI military officer who receives an optical implant after his battle wounds cause him to lose his sight. The player will be presented with the possibility to aid either Colonel Louise James' GDI extremists or Kane's Nod Loyalist forces during the Fourth Tiberium War. Both campaigns' events are considered canon, even though some details of characters' interactions are different.